nephrotic syndrome

What is nephrotic syndrome?

Nephrotic syndrome caused by increase in glomerular permeability to plasma protein. This syndrome can arise from nephritc syndrome when severe proteinuria occur which is daily loss of protein through kidneys is more than 3.5g/day.

Usually loss of proteins more than production by liver causing hypoproteinemia. When there is hypoproteinemia, oncotic pressure in the blood reduced causing formation of edema , edema usually can be detected in infraorbital region and lower limbs. Because of the body has lower protein concentration, liver will try to produce more protein but, there is not enough protein in the body causing liver produce lipoprotein resulting in hyperlipidemia usually formation of LDL, and cholesterol more than 10mmol/L. hyperlipidemia can cause increase risk of atherosclerosis.

Besides that , when there is low protein in the body , the substrate to produce immunoglobulin will decrease causing decrease resistance to infections.

Other than that, hypoproteinemia causing loss of anti coagulation factors resulting in hypercoagulability.